Long‐term outcome of 32 patients with chorea and systemic lupus erythematosus or antiphospholipid antibodies
Identifieur interne : 000026 ( France/Analysis ); précédent : 000025; suivant : 000027Long‐term outcome of 32 patients with chorea and systemic lupus erythematosus or antiphospholipid antibodies
Auteurs : Peggy Reiner [France] ; Damien Galanaud [France] ; Gaëlle Leroux [France] ; Marie Vidailhet [France] ; Julien Haroche [France] ; Du Le Thi Huong [France] ; Camille Francès [France] ; Thomas Papo [France] ; Christian De Gennes [France] ; Lucile Musset [France] ; Bertrand Wechsler [France] ; Zahir Amoura [France] ; Jean-Charles Piette [France] ; Nathalie Costedoat-Chalumeau [France]Source :
- Movement Disorders [ 0885-3185 ] ; 2011-11.
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Abstract
Objective:: The aim of this work was to describe chorea during systemic lupus erythematosus or antiphospholipid antibodies and its long‐term outcome. Methods:: We retrospectively analyzed clinical features, laboratory findings, imaging characteristics, and outcome in a series of 32 patients. Results:: Most patients were women (28 of 32), and mean age at onset of chorea was 20.6 (9–62) years. Chorea was inaugural for 28 patients. Improvement was observed with various treatments. During follow‐up (12.2 ± 11.3 years), severe manifestations of systemic lupus erythematosus were rare. Antiphospholipid antibodies were repeatedly positive for 90% of the patients. Twelve patients developed arterial thrombosis. Prophylactic treatment with antithrombotic therapy might reduce the risk of further thrombosis (8% versus 57%; P = 0.01). Cardiac valvulopathy occurred in 22 patients during follow‐up. Chorea relapsed in 8 cases. Conclusions:: Chorea had a good outcome in itself. This long‐term follow‐up shows, for the first time, that these patients have substantial risk for further arterial thrombosis. © 2011 Movement Disorder Society
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DOI: 10.1002/mds.23863
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Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2011-11">2011-11</date><biblScope unit="volume">26</biblScope><biblScope unit="issue">13</biblScope><biblScope unit="page" from="2422">2422</biblScope><biblScope unit="page" to="2427">2427</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">D4F441530FB5E899F88F218D9988BAF91B915591</idno><idno type="DOI">10.1002/mds.23863</idno><idno type="ArticleID">MDS23863</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>antiphospholipid</term><term>chorea</term><term>lupus</term><term>thrombosis</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Objective:: The aim of this work was to describe chorea during systemic lupus erythematosus or antiphospholipid antibodies and its long‐term outcome. Methods:: We retrospectively analyzed clinical features, laboratory findings, imaging characteristics, and outcome in a series of 32 patients. Results:: Most patients were women (28 of 32), and mean age at onset of chorea was 20.6 (9–62) years. Chorea was inaugural for 28 patients. Improvement was observed with various treatments. During follow‐up (12.2 ± 11.3 years), severe manifestations of systemic lupus erythematosus were rare. Antiphospholipid antibodies were repeatedly positive for 90% of the patients. Twelve patients developed arterial thrombosis. Prophylactic treatment with antithrombotic therapy might reduce the risk of further thrombosis (8% versus 57%; P = 0.01). Cardiac valvulopathy occurred in 22 patients during follow‐up. Chorea relapsed in 8 cases. Conclusions:: Chorea had a good outcome in itself. This long‐term follow‐up shows, for the first time, that these patients have substantial risk for further arterial thrombosis. © 2011 Movement Disorder Society</div></front></TEI><affiliations><list><country><li>France</li></country><settlement><li>Paris</li></settlement></list><tree><country name="France"><noRegion><name sortKey="Reiner, Peggy" sort="Reiner, Peggy" uniqKey="Reiner P" first="Peggy" last="Reiner">Peggy Reiner</name></noRegion><name sortKey="Amoura, Zahir" sort="Amoura, Zahir" uniqKey="Amoura Z" first="Zahir" last="Amoura">Zahir Amoura</name><name sortKey="Costedoat Halumeau, Nathalie" sort="Costedoat Halumeau, Nathalie" uniqKey="Costedoat Halumeau N" first="Nathalie" last="Costedoat-Chalumeau">Nathalie Costedoat-Chalumeau</name><name sortKey="De Gennes, Christian" sort="De Gennes, Christian" uniqKey="De Gennes C" first="Christian" last="De Gennes">Christian De Gennes</name><name sortKey="Frances, Camille" sort="Frances, Camille" uniqKey="Frances C" first="Camille" last="Francès">Camille Francès</name><name sortKey="Galanaud, Damien" sort="Galanaud, Damien" uniqKey="Galanaud D" first="Damien" last="Galanaud">Damien Galanaud</name><name sortKey="Haroche, Julien" sort="Haroche, Julien" uniqKey="Haroche J" first="Julien" last="Haroche">Julien Haroche</name><name sortKey="Huong, Du Le Thi" sort="Huong, Du Le Thi" uniqKey="Huong D" first="Du Le Thi" last="Huong">Du Le Thi Huong</name><name sortKey="Leroux, Gaelle" sort="Leroux, Gaelle" uniqKey="Leroux G" first="Gaëlle" last="Leroux">Gaëlle Leroux</name><name sortKey="Musset, Lucile" sort="Musset, Lucile" uniqKey="Musset L" first="Lucile" last="Musset">Lucile Musset</name><name sortKey="Papo, Thomas" sort="Papo, Thomas" uniqKey="Papo T" first="Thomas" last="Papo">Thomas Papo</name><name sortKey="Piette, Jean Harles" sort="Piette, Jean Harles" uniqKey="Piette J" first="Jean-Charles" last="Piette">Jean-Charles Piette</name><name sortKey="Vidailhet, Marie" sort="Vidailhet, Marie" uniqKey="Vidailhet M" first="Marie" last="Vidailhet">Marie Vidailhet</name><name sortKey="Wechsler, Bertrand" sort="Wechsler, Bertrand" uniqKey="Wechsler B" first="Bertrand" last="Wechsler">Bertrand Wechsler</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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